Molecular insights into
protein structure and function
BIOMOLECULAR NMR GROUP
Group Head, Department of Chemistry
Structure-function studies of potassium channels and toxin inhibitors
Potassium channels (K+-channels) are homotetrameric membrane-embedded assemblies that control the influx/efflux of K+ ions in cells and play critical roles in all biological systems. While much is known about the structural basis for ion selection and gating in such channels, their interaction with various inhibiting toxins is rather enigmatic because of the lack of toxin-channel complex structures. In our lab we aim to unravel the secrets of how toxins bind to the channel opre in a specific manner and block ion conduction.
Welcome to the BIU Solution BioNMR group!
In our group we investigate the structure and dynamics of proteins, and how these impact their function in the biological environment. Our primary tool is solution nuclear magnetic resonance (NMR), a powerful method for understanding the behavior of proteins in close-to-native conditions. Molecular biology, biochemistry, and various biophysical and computational methods are all part of our arsenal aimed at achieving these goals. Visit us to see what we are up to!
Research Group for 'Bio Molecular NMR'
Prof. Jordan Chill
Group Head, Associate Professor
Our vibrant team of post-docs, PhD and MSc students all team up to gain insight into the molecular basis of protein structure and function. For more details on individual projects click here.